A ferroptosis inhibitor (IC50 = 10 nM for erastin-induced ferroptosis in IMR-32 cells); decreases iron-induced plasma LDH levels in a mouse model of acute iron poisoning at 20 µmol/kg; not toxic to mice at 20 µmol/kg for four weeks

UAMC-3203 – 500 µg

Brand:
Cayman
CAS:
2271358-64-4
Storage:
-20
UN-No:
- /

UAMC-3203 is an inhibitor of ferroptosis that has an IC50 value of 10 nM for inhibition of erastin-induced ferroptosis in IMR-32 neuroblastoma cells.{47300} It decreases iron-induced plasma lactate dehydrogenase (LDH) levels in a mouse model of acute iron poisoning when administered at a dose of 20 µmol/kg. It is not toxic to mice following chronic administration of a 20 µmol/kg dose for four weeks. UAMC-3203 has increased solubility and a longer half-life in mouse, rat, and human microsomes and isolated plasma than the ferroptosis inhibitor ferrostatin-1 (Item No. 17729). In an in silico membrane dynamics study, UAMC-3203 was incorporated into a phospholipid bilayer.  

 

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SKU: 26525 - 500 µg Category:

Description

A ferroptosis inhibitor (IC50 = 10 nM for erastin-induced ferroptosis in IMR-32 cells); decreases iron-induced plasma LDH levels in a mouse model of acute iron poisoning at 20 µmol/kg; not toxic to mice at 20 µmol/kg for four weeks

Formal name: 4-(cyclohexylamino)-3-[(phenylmethyl)amino]-N-[2-(1-piperazinyl)ethyl]-benzenesulfonamide

Synonyms: 

Molecular weight: 471.7

CAS: 2271358-64-4

Purity: ≥98%

Formulation: A solution in ethanol

Product Type|Biochemicals|Ox Stress Reagents||Research Area|Cell Biology|Cell Death|Ferroptosis

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