A stable analog of PGH2 and a TP receptor agonist; stimulates shape change in human platelets without a measureable increase in Ca2+ with an EC50 value of 1.8 nM

U-44069 – 10 mg

Brand:
Cayman
CAS:
56985-32-1
Storage:
-20
UN-No:
De Minimis - 1231 / 3

U-44069 is a stable analog of the endoperoxide PGH2 (Item No. 17020) and a TP receptor agonist. It stimulates shape change in human platelets without a measurable increase in [Ca2+] with an EC50 value of 1.8 nM.{485} U-44069 has an EC50 value of 3 µM and 54 nM for platelet aggregation and phosphatidate formation in human platelets, respectively.{713}  

 

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Description

A stable analog of PGH2 and a TP receptor agonist; stimulates shape change in human platelets without a measureable increase in Ca2+ with an EC50 value of 1.8 nM

Formal name: 9,11-dideoxy-9α,11α-epoxymethano-prosta-5Z,13E-dien-1-oic acid

Synonyms:  9,11-dideoxy-9α,11α-epoxymethano PGF2α|9,11-dideoxy-9α,11α-epoxymethano Prostaglandin F2α|9,11-epoxymethano Prostaglandin H2

Molecular weight: 350.5

CAS: 56985-32-1

Purity: ≥98%

Formulation: A solution in methyl acetate

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Cardiovascular System|Blood|Coagulation & Hemostasis||Research Area|Cardiovascular System|Cardiovascular Diseases|Atherosclerosis||Research Area|Cardiovascular System|Vasculature||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway

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