A cell permeable drug that inhibits cholesterol trafficking from late endosomes/lysosomes to the ER

U-18666A – 25 mg

Brand:
Cayman
CAS:
3039-71-2
Storage:
-20
UN-No:
Non-Hazardous - /

Impaired trafficking of cholesterol to or from the endoplasmic reticulum (ER) has been implicated in many disease states including Neimann-Pick disease type C (NPC), Alzheimers disease and atherosclerosis. U-18666A is a cell permeable drug that inhibits cholesterol trafficking. It inhibits cholesterol transport from late endosomes/lysosomes to the endoplasmic reticulum (ER), but not cholesterol transport to the plasma membrane as demonstrated in many cell types including macrophages, primary cortical neurons and primary fibroblasts.{14577,14579,14578} In macrophages, micromolar concentrations of U-18666A inhibit multiple pathways of cholesterol trafficking from late endosomes, whereas nanomolar concentrations impair cholesterol trafficking to the ER, a response similar to that found in NPC. U-18666A inhibits oxidosqualene cyclase at high (>0.5 mM) concentrations and oral doses (10 mg/kg) induces cataracts in rats.{14577}  

 

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SKU: 10009085 - 25 mg Category:

Description

A cell permeable drug that inhibits cholesterol trafficking from late endosomes/lysosomes to the ER, but not to the plasma membrane

Formal name: 3β-[2-(diethylamino)ethoxy]-androst-5-en-17-one, monohydrochloride

Synonyms: 

Molecular weight: 424.1

CAS: 3039-71-2

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Lipids|Sterol Lipids||Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cardiovascular System|Lipids & Lipoproteins|Storage & Transport||Research Area|Lipid Biochemistry|Lipid Transport||Research Area|Lipid Biochemistry|Sterol Lipids||Research Area|Neuroscience

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