A phenol with diverse biological activities; fungicidal against H. capsulatum and C. posadasii (MFCs = 170-710 and 1

Tyrosol – 250 g

Brand:
Cayman
CAS:
501-94-0
Storage:
-20
UN-No:
Non-Hazardous - /

Tyrosol is a phenol that has been found in olives and olive oil and has diverse biological activities.{47483,47484,47485,47486} It is fungicidal against H. capsulatum and C. posadasii with minimum fungicidal concentration (MFC) values of 170-710 and 1,420 μg/ml, respectively.{47483} Tyrosol (70-280 mg/kg) increases survival and pulmonary superoxide dismutase (SOD) activity and decreases pulmonary macrophage and neutrophil infiltration, edema, inflammation, and myeloperoxidase (MPO) activity in a mouse model of LPS-induced acute lung injury.{47484} It reduces aqueous humor TNF-α, nitric oxide (NO), and prostaglandin E2 (PGE2; Item No. 14010) levels and cellular infiltration in a rat model of ocular endotoxin-induced uveitis (EIU).{47485} Tyrosol also decreases erythrocyte aggregation, increases the oxygen transport capacity index (OTCI), and abolishes cortical microvascular rarefaction in spontaneously hypertensive rats.{47486}  

 

Available on backorder

Add to quotes
SKU: 27600 - 250 g Category:

Description

A phenol with diverse biological activities; fungicidal against H. capsulatum and C. posadasii (MFCs = 170-710 and 1,420 μg/ml, respectively); increases survival and pulmonary SOD activity and decreases pulmonary macrophage and neutrophil infiltration, edema, inflammation, and MPO activity in a mouse model of LPS-induced acute lung injury

Formal name: 4-hydroxy-benzeneethanol

Synonyms:  p-HPEA|NSC 59876

Molecular weight: 138.2

CAS: 501-94-0

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Natural Products|Polyphenols||Research Area|Immunology & Inflammation||Research Area|Neuroscience|Ophthalmology||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen|Superoxide Dismutase

Related products

  • A zwitterionic glycerophospholipid commonly used in the formation of lipid monolayers

    1,2-Dipalmitoyl-sn-glycero-3-PC – 50 mg

    1,2-Dipalmitoyl-sn-glycero-3-PC (DPPC) is a zwitterionic glycerophospholipid commonly used in the formation of lipid monolayers, bilayers, and liposomes for use in a variety of applications.{14480,24261,14478,14479} It has been used in the formation of proteoliposomes for implantation of γ-glutamyl transpeptidase into human erythrocyte membranes.{14478} Incorporation of glycosphingolipid antigens into DPPC-containing liposomes increases the immunogenicity of the antigens in mice.{14479}  

     

    Brand:
    Cayman
    SKU:10009473 - 50 mg

    Available on backorder

    Add to quotes
    Add to quotes
    View product page
  • A potent inhibitor of Cdk2/cyclin E with an IC50 value of 0.1 µM; also inhibits Cdk7/cyclin H

    (R)-Roscovitine – 1 mg

    Cyclin-dependent kinases (CDKs) are key regulators of cell cycle progression and are therefore promising targets for cancer therapy. (R)-Roscovitine is a potent inhibitor of Cdk2/cyclin E with an IC50 value of 0.1 µM.{14988} It also inhibits Cdk7/cyclin H, Cdk5/p35, and cell division cycle (cdc)/cyclin B with IC50 values of 0.49, 0.16, and 0.65 µM, respectively.{14987,14988,14991} (R)-Roscovitine inhibits the growth of rapidly proliferating cells with an average IC50 value of 15.2 µM against a panel of 19 human tumor cell lines.{14988} In murine models of polycystic kidney disease, (R)-roscovitine effectively inhibited disease progression at doses of 50-100 mg/kg.{14564}  

     

    Brand:
    Cayman
    SKU:10009569 - 1 mg

    Available on backorder

    Add to quotes
    Add to quotes
    View product page
  • A potent inhibitor of Cdk2/cyclin E with an IC50 value of 0.1 µM; also inhibits Cdk7/cyclin H

    (R)-Roscovitine – 10 mg

    Cyclin-dependent kinases (CDKs) are key regulators of cell cycle progression and are therefore promising targets for cancer therapy. (R)-Roscovitine is a potent inhibitor of Cdk2/cyclin E with an IC50 value of 0.1 µM.{14988} It also inhibits Cdk7/cyclin H, Cdk5/p35, and cell division cycle (cdc)/cyclin B with IC50 values of 0.49, 0.16, and 0.65 µM, respectively.{14987,14988,14991} (R)-Roscovitine inhibits the growth of rapidly proliferating cells with an average IC50 value of 15.2 µM against a panel of 19 human tumor cell lines.{14988} In murine models of polycystic kidney disease, (R)-roscovitine effectively inhibited disease progression at doses of 50-100 mg/kg.{14564}  

     

    Brand:
    Cayman
    SKU:10009569 - 10 mg

    Available on backorder

    Add to quotes
    Add to quotes
    View product page
  • A small molecule activator of stem cell renewal that allows the propagation of OG2 mES cells for at least 10 passages in an undifferentiated state; activity is mediated by the combined inhibition of RasGAP and ERK1 with Kd values of 98 and 212 nM

    SC-1 – 10 mg

    The maintenance of embryonic stem cells in culture typically requires feeder cells and various exogenous factors found in serum. Murine embryonic stem (mES) cells can be maintained in the absence of feeder cells and serum but require the leukemia inhibitor factor (LIF) and bone morphogenic protein (BMP) to prevent differentiation and promote self-renewal. SC-1 is a small molecule activator of stem cell renewal that allows the propagation of OG2 mES cells for at least 10 passages in an undifferentiated state.{14533} The activity of SC-1 is mediated by the combined inhibition of RasGAP and ERK1 with Kd values of 98 and 212 nM, respectively.{14533} Inhibition of RasGAP increases Ras signaling via the PI3-kinase pathway which promotes self-renewal, whereas inhibition of ERK blocks differentiation.  

     

    Brand:
    Cayman
    SKU:10009557 - 10 mg

    Available on backorder

    Add to quotes
    Add to quotes
    View product page