Immunogen: Native rat tyrosine hydroxylase purified from pheochromocytoma • Host: Sheep • Species Reactivity: (+) Human

Tyrosine Hydroxylase (rat, native) Polyclonal Antibody – 100 µl

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Cayman
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Tyrosine hydroxylase (TH) catalyzes the conversion of tyrosine to L-DOPA, which is the rate-limiting step in the biosynthesis of the catecholamines dopamine, norepinephrine, and epinephrine.{56214} It assembles into tetramers, with each monomer comprised of an N-terminal regulatory domain with three serine residues at positions 19, 31, and 40 that are subject to regulatory phosphorylation, a central catalytic domain, and a C-terminal tetramerization domain. TH is expressed in dopaminergic neurons in the olfactory bulb, diencephalon, substantia nigra, ventral tegmental area, and retinal amacrine cells, adrenergic and noradrenergic cells in the hypothalamus, medulla, and locus coeruleus (LC), as well as sympathetic ganglia and adrenal chromaffin cells. Due to its expression in catecholaminergic neurons, TH has been used as a marker of these cells in the brain.{56215} Mutations in TH have been found in patients with tyrosine hydroxylase deficiency, infantile parkinsonism, and progressive infantile encephalopathy.{56216,56217} Cayman’s Tyrosine Hydroxylase (rat, native) Polyclonal Antibody can be used for immunocytochemistry (ICC), immunohistochemistry (IHC), and Western blot (WB) applications. The antibody recognizes TH at approximately 60 kDa from human, mouse, rabbit, and rat samples.  

 

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SKU: 29299 - 100 µl Category:

Description

Immunogen: Native rat tyrosine hydroxylase purified from pheochromocytoma • Host: Sheep • Species Reactivity: (+) Human, Mouse, Rabbit, Rat • Applications: ICC, IHC, WB • MW = ~60 kDa

Synonyms: TH|Tyrosine 3-hydroxylase|Tyrosine 3-monooxygenase

Immunogen: Native rat tyrosine hydroxylase purified from pheochromocytoma

Formulation: 100 µl affinity-purified polyclonal antibody from pooled serum

Isotype:

Applications: ICC, IHC, WB

Origin:

Stability: 365 days

Application|Immunocytochemistry||Application|Immunohistochemistry||Application|Western Blot||Product Type|Antibodies|Polyclonal Antibodies||Research Area|Neuroscience|Neurodegenerative Disorders|Parkinson’s Disease

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