A selective S1P3 receptor antagonist (Ki = 110 nM); suppresses FTY720-induced S1P3 receptor-mediated coronary flow in isolated perfused rat hearts; also inhibit S1P-induced breast cancer stem cell expansion in vitro

TY 52156 – 5 mg

Brand:
Cayman
CAS:
934369-14-9
Storage:
-20
UN-No:
Non-Hazardous - /

TY 52156 is a selective sphingosine-1-phosphate receptor 3 (SIP3) antagonist (Ki = 110 nM).{31203} It preferentially inhibits the S1P-induced increase in intracellular calcium in Chinese hamster ovary cells expressing S1P3 over cell expressing S1P1, S1P2, or S1P4.{31203} TY 52156 has been shown to suppress FTY720-induced S1P3 receptor-mediated coronary flow in isolated perfused rat hearts.{31203} TY 52156 can also inhibit S1P-induced breast cancer stem cell expansion in vitro.{31202}  

 

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Description

A selective S1P3 receptor antagonist (Ki = 110 nM); suppresses FTY720-induced S1P3 receptor-mediated coronary flow in isolated perfused rat hearts; also inhibit S1P-induced breast cancer stem cell expansion in vitro

Formal name: N-(4-chlorophenyl)-3,3-dimethyl-2-oxobutanimidic acid, 2-(4-chlorophenyl)hydrazide

Synonyms: 

Molecular weight: 364.3

CAS: 934369-14-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Cancer|Cancer Stem Cell Research|Proliferation||Research Area|Cardiovascular System|Heart||Research Area|Cell Biology|Stem Cell Research||Research Area|Lipid Biochemistry|Sphingolipids

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