An inhibitor of the Bcl-2 family proteins Bcl-2

TW-37 – 50 mg

Brand:
Cayman
CAS:
877877-35-5
Storage:
-20
UN-No:
Non-Hazardous - /

TW-37 is an inhibitor of the Bcl-2 family proteins Bcl-2, Mcl-1, and Bcl-xL (Kis = 120, 260, and 1,100 nM, respectively).{33641,33642} It induces apoptosis, inhibits migration and capillary sprouting, and blocks the expression of the angiogenic chemokines CXCL1 and CXCL8 in endothelial cells.{33642} TW-37 decreases the density of functional human microvessels in the severe combined immunodeficient mouse model of human angiogenesis when administered intravenously.{33642} It has apoptotic action against leukemia, lymphoma, and pancreatic cancer cells.{25683}  

 

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Description

An inhibitor of the Bcl-2 family proteins Bcl-2, Mcl-1, and Bcl-xL (Kis = 120, 260, and 1,100 nM, respectively); induces apoptosis, inhibits migration and capillary sprouting in endothelial cells; has apoptotic action against leukemia, lymphoma, and pancreatic cancer cells

Formal name: N-[4-[[2-(1,1-dimethylethyl)phenyl]sulfonyl]phenyl]-2,3,4-trihydroxy-5-[[2-(1-methylethyl)phenyl]methyl]-benzamide

Synonyms: 

Molecular weight: 573.7

CAS: 877877-35-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals||Research Area|Cancer|Angiogenesis||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Migration & Metastasis

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