A specific inhibitor of N-linked glycoslylation that blocks the first step of glycoprotein synthesis and induces protein unfolding; impairs the function of several receptor tyrosine kinases

Tunicamycin – 1 mg

Brand:
Cayman
CAS:
11089-65-9
Storage:
-20
UN-No:
De Minimis - 3462 / 6.1

N-linked glycosylation is a highly regulated post-translational modification that is involved in protein folding and conformation, oligomerization, sorting, cell-cell interactions, and targeting of proteins to sub- or extra-cellular locations. It is initiated in the endoplastic reticulum with the transfer of a carbohydrate moiety to an asparagine residue within a specific amino acid consensus sequence and then further processed in the Golgi whereupon a mature glycoprotein is exported through the secretory machinery to the plasma membrane. Tunicamycin, a mixture of nucleoside antibiotics, is a specific inhibitor of N-linked glycoslylation that blocks the first step of glycoprotein synthesis thereby inducing protein unfolding. At 500 nM, it can impair the function of several receptor tyrosine kinases, including EGFR, ErbB2, ErbB3, and IGF-IR.{20913} Also at 500 nM, it radiosensitizes U251 glioma and BXPC3 pancreatic adenocarcinoma cells to chemotherapy.{20913} Tunicamycin impairs ALK phosphorylation and disrupts pro-survival signaling and cell viability in various neuroblastoma cell lines (IC50s range from 20 – 500 nM).{20914} Tunicamycin can also inhibit protein palmitoylation.{20912}  

 

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SKU: 11445 - 1 mg Category:

Description

A specific inhibitor of N-linked glycoslylation that blocks the first step of glycoprotein synthesis and induces protein unfolding; impairs the function of several receptor tyrosine kinases, including EGFR, ErbB2, ErbB3, IGF-IR, and ALK; radiosensitizes glioma and pancreatic adenocarcinoma cells to chemotherapy (500 nM) and disrupts cell viability in various neuroblastoma cell lines (IC50s 20 – 500 nM)

Formal name:

Synonyms: 

Molecular weight: 845

CAS: 11089-65-9

Purity: ≥95% (mixture of congeners)

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|EGFR/ErbB/HER Family||Product Type|Biochemicals|Kinase Inhibitors|IGF-1R/InsR Family||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Signaling|Growth Factor Receptor Signaling||Research Area|Cell Biology|Cell Signaling|Growth Factor Receptors||Research Area|Cell Biology|Endomembrane System & Vesicular Trafficking|ER Protein Folding

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