An agonist of FFA1/GPR40 (EC50 = 6.16 nM); selective for FFA1 over FFA2 (EC50 = 933 nM); reduces glucose levels in an intraperitoneal glucose tolerance test in mice; reduces glucose levels for at least 29 days with chronic oral dosing in a mouse model of diet-induced obesity

TUG-770 – 10 mg

Brand:
Cayman
CAS:
1402601-82-4
Storage:
-20
UN-No:
De Minimis - 3077 / 9

TUG-770 is an agonist of free fatty acid receptor 1 (FFA1/GPR40; EC50 = 6.16 nM for a response to the full FFA1 agonist TUG-20 in a calcium assay in 1311N1 cells).{37557} It is selective for FFA1 over FFA2 (EC50 = 933 nM in a BRET assay). It reduces glucose levels in mice in an intraperitoneal glucose tolerance test in a dose-dependent manner with a maximal reduction at a dose of 50 mg/kg. It also reduces glucose levels in an oral glucose tolerance test in a diet-induced obesity mouse model for at least 29 days.  

 

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Description

An agonist of FFA1/GPR40 (EC50 = 6.16 nM); selective for FFA1 over FFA2 (EC50 = 933 nM); reduces glucose levels in an intraperitoneal glucose tolerance test in mice; reduces glucose levels for at least 29 days with chronic oral dosing in a mouse model of diet-induced obesity

Formal name: 4-[2-[2-(cyanomethyl)phenyl]ethynyl]-2-fluoro-benzenepropanoic acid

Synonyms: 

Molecular weight: 307.3

CAS: 1402601-82-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes

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