Potent HDAC6 inhibitor (IC50 = 15 nM) with 1

Tubastatin A – 10 mg

Brand:
Cayman
CAS:
1252003-15-8
Storage:
-20
UN-No:
Non-Hazardous - /

Tubastatin A is a potent HDAC6 inhibitor with an IC50 value of 15 nM.{18338} Comparatively, it demonstrates over 1,000-fold selectivity against all other HDAC isoforms (IC50s > 16 μM), excluding HDAC8 (IC50 = 0.9 μM).{18338} Tubastatin A induces α-tubulin hyperacetylation at 2.5 μM in primary cortical neuron cultures. In a model of oxidative stress induced by glutathione depletion, tubastatin A displays dose-dependent neuronal protection of primary cortical neuron cultures at 5-10 μM.{18338}  

 

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Description

Potent HDAC6 inhibitor (IC50 = 15 nM) with 1,000-fold selectivity against all other HDAC isoforms (IC50s > 16 μM), excluding HDAC8 (IC50 = 0.9 μM); displays dose-dependent neuronal protection of primary cortical neuron cultures at 5-10 μM

Formal name: N-hydroxy-4-[(1,2,3,4-tetrahydro-2-methyl-5H-pyrido[4,3-b]indol-5-yl)methyl]-benzamide

Synonyms: 

Molecular weight: 335.4

CAS: 1252003-15-8

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Deacetylases||Research Area|Epigenetics, Transcription, & Translation|Erasers|Histone Deacetylation||Research Area|Neuroscience

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