A selective HDAC6 inhibitor (IC50 = 4 nM) used as a biochemical tool to control microtubule-dependent intracellular trafficking

Tubacin – 5 mg

Brand:
Cayman
CAS:
537049-40-4
Storage:
-20
UN-No:
Non-Hazardous - /

Tubacin is a tubulin acetylation inducer that selectively inhibits histone deacetylase (HDAC) 6 (IC50 = 4 nM).{18338} In comparison, it demonstrates at least 300-fold selectivity against all other HDAC isoforms (IC50s range from 1.3-17.3 μM).{18338} Tubacin induces α-tubulin hyperacetylation at 2.5 μM in primary cortical neuron cultures.{18338} Tubacin inhibition of HDAC6 has been used as a biochemical tool to control microtubule-dependent intracellular trafficking, to manipulate the aggresome formation of misfolded proteins in certain diseases, and to study the dynamics of cellular adhesion.{22754,16624,21803}  

 

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Description

A selective HDAC6 inhibitor (IC50 = 4 nM) used as a biochemical tool to control microtubule-dependent intracellular trafficking, to manipulate the aggresome formation of misfolded proteins in certain diseases, and to study the dynamics of cellular adhesion

Formal name: N1-[4-[(2R,4R,6S)-4-[[(4,5-diphenyl-2-oxazolyl)thio]methyl]-6-[4-(hydroxymethyl)phenyl]-1,3-dioxan-2-yl]phenyl]-N8-hydroxy-octanediamide

Synonyms: 

Molecular weight: 721.9

CAS: 537049-40-4

Purity: ≥90%

Formulation: A crystalline solid

Product Type|Biochemicals|Microtubule Dynamics||Product Type|Biochemicals|Small Molecule Inhibitors|Deacetylases||Research Area|Epigenetics, Transcription, & Translation|Erasers|Histone Deacetylation

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