A selective inhibitor of LPCAT2 (IC50s = 0.47 versus 3.02 µM for human LPCAT2 and LPCAT1

TSI-01 – 25 mg

Brand:
Cayman
CAS:
704878-75-1
Storage:
-20
UN-No:
Non-Hazardous - /

Platelet-activating factor (PAF) is a pro-inflammatory phospholipid mediator that is rapidly synthesized by lyso-PAF acetyltransferase (lyso-PAFAT) in response to extracellular stimuli. Two types of lyso-PAFAT have been identified: lysophosphatidylcholine acyltransferase (LPCAT)1, which is mostly expressed in the lungs, and LPCAT2, which is expressed in inflammatory cells. TSI-01 is a selective inhibitor of LPCAT2 (IC50s = 0.47 versus 3.02 µM for human LPCAT2 and LPCAT1, respectively).{28871} At 60 µM it was shown to suppress PAF biosynthesis in mouse peritoneal macrophages stimulated with a calcium ionophore.{28871}  

 

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Description

A selective inhibitor of LPCAT2 (IC50s = 0.47 versus 3.02 µM for human LPCAT2 and LPCAT1, respectively) that can suppress PAF biosynthesis in mouse peritoneal macrophages stimulated with a calcium ionophore

Formal name: 4-(3,4-dichloro-2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-benzoic acid, 1-methylethyl ester

Synonyms: 

Molecular weight: 328.2

CAS: 704878-75-1

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Acetyltransferases||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Lipid Biochemistry|Glycerophospholipids|Acyltransferases

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