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Tryptophan Hydroxylase (Phospho-Ser260) Polyclonal Antibody – 1 ea

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Cayman
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TPH catalyzes the 5-hydroxylation of tryptophan, which is the first step in the biosynthesis of indoleamines (serotonin and melatonin).{14424} In mammals, serotonin biosynthesis occurs predominantly in neurons which originate in the Raphe nuclei of the brain, and melatonin synthesis takes place within the pineal gland. TPH catalyzes the 5-hydroxylation of tryptophan, which is the first step in the biosynthesis of indoleamines (serotonin and melatonin).{14424} In mammals, serotonin biosynthesis occurs predominantly in neurons which originate in the Raphe nuclei of the brain, and melatonin synthesis takes place within the pineal gland. Although TPH catalyzes the same reaction within the Raphe nuclei and the pineal gland, TPH activity is rate-limiting for serotonin but not melatonin biosynthesis. Serotonin functions mainly as a neurotransmitter, whereas melatonin is the principal hormone secreted by the pineal gland. The activity of TPH is enhanced by phosphorylation by cAMP-dependent protein kinase (PKA) and Ca2+/calmodulin kinase II (CaM K II).{14425,14426} CaM K II phosphorylate Ser260 which lies within the regulatory domain of TPH.{14425}  

 

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SKU: 10009398 - 1 ea Category:

Description

Antigen: phosphopeptide corresponding to amino acid residues surrounding phospho-Ser260 of rat TPH · Host: rabbit · Cross-reactivity: (+) human and rat TPH; expected to react with bovine, canine, chicken, mouse, and zebrafish TPH · Application: WB

Synonyms: TPH

Immunogen: phosphopeptide corresponding to amino acid residues surrounding phospho-Ser260 of rat tryptophan hydroxylase (TPH)

Formulation: Peptide affinity-purified antibody

Isotype:

Applications: WB

Origin: Animal/Rabbit

Stability: 365 days

Application|Western Blot||Product Type|Antibodies|Polyclonal Antibodies||Research Area|Neuroscience|Behavioral Neuroscience|Sleep & Biological Rhythms

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