The major bioactive constituent of T. wilfordii Hook F.

Triptolide – 1 mg

Brand:
Cayman
CAS:
38748-32-2
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

Triptolide is the major bioactive constituent of T. wilfordii Hook F., also known as thunder god vine, a traditional Chinese medicinal herb with known antiproliferative, immunosuppressive, anti-inflammatory, antifertility, and anti-polycystic kidney disease effects. Triptolide binds to and inhibits human dCTP pyrophosphatase 1, a “gatekeeper” enzyme that prevents deleterious halogenated nucleotides from entering DNA synthesis, with a Ki value of 168 μM and an IC50 value of 7-10 nM.{22058} Triptolide has also been shown to inhibit LPS-stimulated induction of cyclooxygenase 2 mRNA and synthesis of prostaglandin E2 in human peripheral blood monocytes, rheumatoid arthritis synovial fibroblasts, and human neonatal foreskin fibroblasts with an IC50 value of 0.04 μM.{22057}  

 

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SKU: 11973 - 1 mg Category:

Description

The major bioactive constituent of T. wilfordii Hook F., with known antiproliferative, immunosuppressive, anti-inflammatory, antifertility, and antipolycystic kidney disease effects; inhibits human DCTPP1 (Ki = 168 μM; IC50 = 7-10 nM) and COX-2 (IC50 = 0.04 μM)

Formal name: 3bS,4,4aS,6R,6aR,7aS,7bS,8bS,9,10-decahydro-6-hydroxy-8b-methyl-6a-(1-methylethyl)-trisoxireno[4b,5aS:6,7:8aS,9]phenanthro[1,2-c]furan-1(3H)-one

Synonyms:  NSC 163062|PG 490

Molecular weight: 360.4

CAS: 38748-32-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products||Product Type|Biochemicals|Small Molecule Inhibitors|Phosphatases||Research Area|Immunology & Inflammation|Autoimmunity|Rheumatoid Arthritis||Research Area|Immunology & Inflammation|Immunosuppressants||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Prostaglandins||Research Area|Immunology & Inflammation|Innate Immunity

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