An inhibitor of DHCR24 in the cholesterol biosynthetic pathway (Ki = 0.523 µM); has antitumor properties; decreases Hedgehog signaling in cancer cells

Triparanol – 500 µg

Brand:
Cayman
CAS:
78-41-1
Storage:
-20
UN-No:
Non-Hazardous - /

Triparanol is a 24-dehydro cholesterol reductase (DHCR24) inhibitor (Ki = 0.523 µM), which is an enzyme involved in the biosynthesis of cholesterol.{34169,34196} It has antitumor properties, such as decreasing proliferation and inducing apoptosis in many cancer cell lines and slowing tumor growth in a mouse xenograft model.{34170} It can also decrease Hedgehog pathway signaling in cancer cells. Formulations containing triparanol were discontinued in the 1960s due to serious adverse side effects, including rapid cataract development.{34171,34172}  

 

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Description

An inhibitor of DHCR24 in the cholesterol biosynthetic pathway (Ki = 0.523 µM); has antitumor properties; decreases Hedgehog signaling in cancer cells

Formal name: 4-chloro-α-[4-[2-(diethylamino)ethoxy]phenyl]-α-(4-methylphenyl)-benzeneethanol

Synonyms:  MER-29|NSC 65345

Molecular weight: 438

CAS: 78-41-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|MMPs||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Signaling|Hedgehog Signaling||Research Area|Cardiovascular System|Lipids & Lipoproteins|Cholesterol Metabolism||Research Area|Cell Biology|Cell Signaling|Hedgehog Signaling

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