A tricyclic antidepressant compound that antagonizes several types of neurotransmitter receptors: H1 (Kd = 0.27 nM)

Trimipramine (maleate) – 1 g

Brand:
Cayman
CAS:
521-78-8
Storage:
-20
UN-No:
Non-Hazardous - /

Trimipramine (maleate) is a tricyclic antidepressant compound that antagonizes several types of neurotransmitter receptors. It is a potent antagonist of histamine H1 (Kd = 0.27 nM), serotonin 5-HT2A, and α1-adrenergic (Kd = 24 nM) receptors.{25914} It demonstrates moderate antagonist activity at dopamine D2 (Kd = 180 nM) and muscarinic acetylcholine (Kd = 58 nM) receptors and weak activity at 5-HT2C, D1, α2-adrenergic (Kd = 680 nM) receptors.{25914} Trimipramine (maleate) is a weak to moderate reuptake inhibitor of serotonin (Ki = 149 nM for SERT), and an extremely weak inhibitor of norepinephrine (Ki = 2.5 µM for NET) and dopamine (Ki = 3.8 µM for DAT) reuptake in slices of rat cerebral cortex.{30236,22877}  

 

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Description

A tricyclic antidepressant compound that antagonizes several types of neurotransmitter receptors: H1 (Kd = 0.27 nM), 5-HT2A, α1-adrenergic, D2 (Kd = 180 nM), muscarinic acetylcholine (Kd = 58 nM), 5-HT2C, D1, and α2-adrenergic (Kd = 680 nM) receptors

Formal name: 10,11-dihydro-N,N,β-trimethyl-5H-dibenz[b,f]azepine-5-propanamine(2Z)-2-butenedioate

Synonyms: 

Molecular weight: 410.5

CAS: 521-78-8

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area|Neuroscience|Behavioral Neuroscience|Depression

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