A specific ribonucleotide reductase inhibitor; inhibits growth of human promyelocytic leukemia HL-60 cells (IC50 = 35 µM)

Trimidox (hydrochloride) – 5 mg

Brand:
Cayman
CAS:
95933-75-8
Storage:
-20
UN-No:
Non-Hazardous - /

Ribonucleotide reductase, the rate-limiting enzyme for de novo DNA synthesis, is a common target for chemotherapy. Its increased activity in cancer cells is associated with malignant transformation and proliferation.{14245} Trimidox is a specific ribonucleotide reductase inhibitor that reduces levels of dGTP and dCTP in HL-60 cells, inducing apoptosis via activation of caspases without altering the cell cycle distribution.{14245,15318} Trimidox inhibits growth of human promyelocytic leukemia HL-60 cells with an IC50 value of 35 µM.{14245}  

 

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SKU: 10011124 - 5 mg Category:

Description

A specific ribonucleotide reductase inhibitor; inhibits growth of human promyelocytic leukemia HL-60 cells (IC50 = 35 µM)

Formal name: N,3,4,5-tetrahydroxy-benzenecarboximidamide, monohydrochloride

Synonyms:  CF 233 (hydrochloride)

Molecular weight: 220.6

CAS: 95933-75-8

Purity: >98%

Formulation: A crystalline solid

Product Type|Biochemicals|Nucleotides/Nucleosides||Product Type|Biochemicals|Small Molecule Inhibitors|Nucleic Acid Turnover/Signaling||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Metabolism

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