An internal standard for the quantification of trimethoprim by GC- or LC-MS

Trimethoprim-d3 – 500 µg

Brand:
Cayman
CAS:
1189923-38-3
Storage:
-20
UN-No:
Non-Hazardous - /

Trimethoprim-d3 is intended for use as an internal standard for the quantification of trimethoprim (Item No. 16473) by GC- or LC-MS. Trimethoprim is a synthetic antibiotic that inhibits dihydrofolate reductase (DHFR), which is necessary for the synthesis of purines, amino acids, and thymidylic acid.{27030,27031} Trimethoprim shows prominent selectivity for bacterial DHFR over mammalian DHFR (IC50s = 5 and 30,000 nM, respectively).{27031} Formulations containing trimethoprim, commonly used in combination with sulfamethoxazole to minimize acquired resistance, have been used in the treatment of urinary tract infections.  

 

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SKU: 26119 - 500 µg Category:

Description

An internal standard for the quantification of trimethoprim by GC- or LC-MS

Formal name: 5-(3,5-dimethoxy-4-(methoxy-d3)benzyl)pyrimidine-2,4-diamine

Synonyms: 

Molecular weight: 293.3

CAS: 1189923-38-3

Purity: ≥99% deuterated forms (d1-d3)

Formulation: A solid

Application|Mass Spectrometry||Product Type|Biochemicals|Analytical Standards||Product Type|Biochemicals|Antibiotics||Product Type|Biochemicals|Isotopically Labeled Standards|Deuterium||Product Type|Biochemicals|Small Molecule Inhibitors|Amino Acid Turnover||Product Type|Biochemicals|Small Molecule Inhibitors|Nucleic Acid Turnover/Signaling||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases

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