A synthetic antibiotic that inhibits dihydrofolate reductase (DHFR)

Trimethoprim – 50 g

Brand:
Cayman
CAS:
738-70-5
Storage:
-20
UN-No:
Non-Hazardous - /

Trimethoprim is a synthetic antibiotic that inhibits dihydrofolate reductase (DHFR), which is necessary for the synthesis of purines, amino acids, and thymidylic acid.{27030,27031} Trimethoprim shows prominent selectivity for bacterial DHFR over mammalian DHFR (IC50s = 5 and 30,000 nM, respectively).{27031} Formulations containing trimethoprim, commonly used in combination with sulfamethoxazole to minimize acquired resistance, have been used in the treatment of urinary tract infections.  

 

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Description

A synthetic antibiotic that inhibits dihydrofolate reductase (DHFR), with prominent selectivity for bacterial DHFR over mammalian DHFR (IC50s = 5 and 30,000 nM, respectively)

Formal name: 5-[(3,4,5-trimethoxyphenyl)methyl]-2,4-pyrimidinediamine

Synonyms:  NIH 204|NSC 106568

Molecular weight: 290.3

CAS: 738-70-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antibiotics||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases

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