A piperazine derivative that decreases fatty acid β-oxidation by reversibly inhibiting mitochondrial long-chain 3-ketoacyl thiolase (IC50 = 75 nM); stimulates glucose oxidation

Trimetazidine (hydrochloride) – 100 mg

Brand:
Cayman
CAS:
13171-25-0
Storage:
-20
UN-No:
Non-Hazardous - /

Trimetazidine (hydrochloride) (Item No. 18165) is an analytical reference standard that is structurally categorized as a piperazine. It decreases fatty acid β-oxidation by reversibly inhibiting mitochondrial long-chain 3-ketoacyl thiolase (IC50 = 75 nM).{29346} This, in turn, stimulates glucose oxidation.{29348,29347} In ischemic heart, trimetazidine reduces ischemia/reperfusion injury in clinical trials.{29349} Compounds that reduce mitochondrial fatty acid β-oxidation, including trimetazidine, have shown clinical efficacy against chronic stable angina in clinical trials.{29347,29349} In part because of its ability to ameliorate testosterone cardiotoxicity, trimetazidine has been classified as a prohibited substance by the World Anti-Doping Agency.{30524,30525} This product is intended for research and forensic applications.  

 

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Description

A piperazine derivative that decreases fatty acid β-oxidation by reversibly inhibiting mitochondrial long-chain 3-ketoacyl thiolase (IC50 = 75 nM); stimulates glucose oxidation, reducing ischemia/reperfusion injury in ischemic hearts

Formal name: 1-[(2,3,4-trimethoxyphenyl)methyl]-piperazine, dihydrochloride

Synonyms: 

Molecular weight: 339.3

CAS: 13171-25-0

Purity: ≥98%

Formulation: A crystalline solid

Application|Mass Spectrometry||Product Type|Biochemicals|Analytical Standards||Product Type|Biochemicals|Drugs of Abuse||Research Area|Cardiovascular System|Cardiovascular Diseases|Myocardial Infarction||Research Area|Cell Biology|Mitochondrial Biology||Research Area|Forensic Chemistry & Toxicology|Hallucinogens|Piperazines||Research Area|Forensic Chemistry & Toxicology|Performance-Enhancing Drugs||Research Area|Forensic Chemistry & Toxicology|Stimulants|Piperazines

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