A dihydrochalcone glucoside with diverse biological activities; reduces survival of Bel 7402 and HepG2 cancer cells at 100 μM; increases SOD and GPX activity (EC50 = 129 and 128 μM

Trilobatin – 1 mg

Brand:
Cayman
CAS:
4192-90-9
Storage:
-20
UN-No:
Non-Hazardous - /

Trilobatin is a dihydrochalcone glucoside and derivative of phloretin (Item No. 14452) that has been found in Rooibos (A. linearis) tea and has diverse biological activities.{45242,45241,45240,45239,45238} It reduces survival of Bel 7402 and HepG2 cancer cells when used at a concentration of 100 μM.{45241} Trilobatin increases superoxide dismutase (SOD) and glutathione peroxidase (GPX) activity (EC50s = 129 and 128 μM, respectively) and inhibits lipid peroxidation (IC50 = 88 μM) in rat liver homogenates.{45240} Pretreatment with trilobatin reduces hydrogen peroxide-induced cell death and production of mitochondrial reactive oxygen species (ROS), prevents reduction in the mitochondrial membrane potential, and increases the activity of GPX, SOD2, and isocitrate dehydrogenase 2 (IDH2) in PC12 neuronal cells.{45239} Trilobatin inhibits infection by various HIV-1 strains (IC50s = 2.91-27.11 μM) without inducing cytotoxicity in target cells.{45238}  

 

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SKU: 25837 - 1 mg Category:

Description

A dihydrochalcone glucoside with diverse biological activities; reduces survival of Bel 7402 and HepG2 cancer cells at 100 μM; increases SOD and GPX activity (EC50 = 129 and 128 μM, respectively) and inhibits lipid peroxidation (IC50 = 88 μM, respectively) in rat liver homogenates; reduces hydrogen peroxide-induced cell death and production of mitochondrial ROS, prevents reduction in the mitochondrial membrane potential, and increases the activity of GPX, SOD2, and IDH2 in PC12 neuronal cells; inhibits infection by various HIV-1 strains (IC50s = 2.91-27.11 μM)

Formal name: 1-[4-(β-D-glucopyranosyloxy)-2,6-dihydroxyphenyl]-3-(4-hydroxyphenyl)-1-propanone

Synonyms:  Phloretin-4-O-glucoside

Molecular weight: 436.4

CAS: 4192-90-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antivirals||Product Type|Biochemicals|Natural Products|Chalcones||Product Type|Biochemicals|Natural Products|Flavonoids||Product Type|Biochemicals|Natural Products|Glycosides||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Research Area|Cancer|Cell Death||Research Area|Cell Biology|Mitochondrial Biology||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Viral Diseases|HIV & AIDS||Research Area|Neuroscience|Neuroprotection||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Lipid Peroxidation||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen|Gluthathione Peroxidase||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen|Superoxide Dismutase

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