A pyridine alkaloid formed by the methylation of the nitrogen atom of niacin; used to reduce blood glucose levels and to inhibit PPARγ expression in rat models of diabetes; inhibits the migration of hepatocarcinoma cells and renders them more susceptible to apoptosis by reducing Raf/ERK/Nrf2 protein levels and activities of anti-oxidative enzymes further downstream

Trigonelline (chloride) – 1 g

Brand:
Cayman
CAS:
6138-41-6
Storage:
-20
UN-No:
Non-Hazardous - /

Trigonelline is a pyridine alkaloid found in various edible seeds and legumes, including coffee. It is a zwitterion formed by the methylation of the nitrogen atom of niacin (vitamin B3; nicotinic acid) and, as a product of niacin metabolism, is excreted in urine of mammals.{31519} Trigonelline has been used to reduce blood glucose levels and to inhibit PPARγ expression in rat models of diabetes.{31520,31516} It is also reported to inhibit the migration of hepatocarcinoma cells and render them more susceptible to apoptosis by reducing Raf/ERK/Nrf2 protein levels and activities of anti-oxidative enzymes further downstream, such as SOD, catalase, and glutathione peroxidase.{31518,31517}  

 

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SKU: 11904 - 1 g Category:

Description

A pyridine alkaloid formed by the methylation of the nitrogen atom of niacin; used to reduce blood glucose levels and to inhibit PPARγ expression in rat models of diabetes; inhibits the migration of hepatocarcinoma cells and renders them more susceptible to apoptosis by reducing Raf/ERK/Nrf2 protein levels and activities of anti-oxidative enzymes further downstream

Formal name: 3-carboxy-1-methyl-pyridinium, monochloride

Synonyms:  N-methyl Nicotinic Acid betaine

Molecular weight: 173.6

CAS: 6138-41-6

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Alkaloids||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Migration & Metastasis||Research Area|Endocrinology & Metabolism|Cofactors & Vitamins||Research Area|Endocrinology & Metabolism|Hormones & Receptors|PPARs||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen|Catalase||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen|Gluthathione Peroxidase||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen|Superoxide Dismutase

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