A phenothiazine with diverse biological activities; binds to muscarinic receptors in isolated rat corpus striatum (IC50 = 100 μM in a radioligand binding assay); inhibits 5-HT uptake by isolated rat brainstem synaptosomes (IC50 = 0.8 μM); inhibits T. cruzi infection in mouse peritoneal macrophages at 12.5 μM; active against S. aureus

Triflupromazine (hydrochloride) – 1 g

Brand:
Cayman
CAS:
1098-60-8
Storage:
-20
UN-No:
- 2811 / 6.1

Triflupromazine is a phenothiazine with diverse biological activities.{47511,47512,47513,47514} It binds to muscarinic receptors in isolated rat corpus striatum (IC50 = 100 μM in a radioligand binding assay).{47511} Triflupromazine inhibits serotonin (5-HT) uptake by isolated rat brainstem synaptosomes (IC50 = 0.8 μM).{47512} It inhibits T. cruzi infection in mouse peritoneal macrophages when used at a concentration of 12.5 μM.{47513} Triflupromazine is active against S. aureus, shigellae, and vibrios (MICs = 2-100 μg/ml) in vitro and is protective against S. typhimurium infection in mice when administered at a dose of 30 μg per animal.{47514} Formulations containing triflupromazine were previously used as antipsychotics.  

 

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SKU: 27610 - 1 g Category:

Description

A phenothiazine with diverse biological activities; binds to muscarinic receptors in isolated rat corpus striatum (IC50 = 100 μM in a radioligand binding assay); inhibits 5-HT uptake by isolated rat brainstem synaptosomes (IC50 = 0.8 μM); inhibits T. cruzi infection in mouse peritoneal macrophages at 12.5 μM; active against S. aureus, shigellae, and vibrios (MICs = 2-100 μg/ml); protective against S. typhimurium infection in mice at 30 μg/animal

Formal name: N,N-dimethyl-2-(trifluoromethyl)-10H-phenothiazine-10-propanamine, monohydrochloride

Synonyms:  Siquil

Molecular weight: 388.9

CAS: 1098-60-8

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Receptor Pharmacology||Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases|Cholera||Research Area|Infectious Disease|Bacterial Diseases|Food-borne Illnesses||Research Area|Infectious Disease|Bacterial Diseases|Shigellosis||Research Area|Infectious Disease|Parasitic Diseases|Chagas Disease||Research Area|Neuroscience

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