Trifluoperazine-d3 (hydrochloride) – 1 mg

Brand:
Cayman
CAS:
1432064-02-2
Storage:
-20
UN-No:
Non-Hazardous - /

Trifluoperazine-d3 is intended for use as an internal standard for the quantification of trifluoperazine (Item No. 15068) by GC- or LC-MS. Trifluoperazine (TFP) is a phenothiazine compound with anti-adrenergic and anti-dopaminergic actions typical of antipsychotic agents.{24253} It antagonizes adrenergic receptors, with selectivity for α1 over the α2 subtypes (Kis = 24, 653, 163, and 391 nM for α1A, α2A, α2B, and α2C, respectively). TFP binds with much higher affinity to the dopamine D2-like receptor (Kd = 0.96 nM) compared to the dopamine D4-like and the serotonin 5-HT2A receptors (Kds = 44 and 135 nM, respectively).{24252} Furthermore, TFP antagonizes calmodulin (CaM) and alters the calcium-binding properties of calsequestrin (CSQ).{23719,24254} TFP has been shown to activate type-2 ryanodine receptors independently of its CaM and CSQ activity.{24254}  

 

Available on backorder

SKU: 30718 - 1 mg Category:

Description

An internal standard for the quantification of trifluoperazine by GC- or LC-MS


Formal name: 10-[3-(4-methyl-d3-1-piperazinyl)propyl]-2-(trifluoromethyl)-10H-phenothiazine, dihydrochloride

Synonyms:  TFP-d3

Molecular weight: 483.4

CAS: 1432064-02-2

Purity: ≥99% deuterated forms (d1-d3)

Formulation: A solid