An inhibitor of long fatty acid acyl-CoA synthetase (IC50 = 6.3 μM in Raji cells) that interferes with lipid metabolism by inhibiting the de novo synthesis of triglycerides

Triacsin C – 500 µg

Brand:
Cayman
CAS:
76896-80-5
Storage:
-20
UN-No:
Non-Hazardous - /

Triacsin C, originally isolated from Streptomyces sp., is an inhibitor of long fatty acid acyl-CoA synthetase (IC50 = 6.3 μM in Raji cells).{1627} It has been shown to interfere with lipid metabolism by inhibiting the de novo synthesis of triglycerides, diglycerides, and cholesterol esters.{25053} It is also known to act as a hypotensive vasodilator, modulating endothelial nitric oxide synthase repalmitoylation by limiting palmitoyl CoA availability.{25054} Triacsin C can inhibit pancreatic β-cell function by suppressing the mobilization of intracellular calcium.{25055}  

 

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SKU: 10007448 - 500 µg Category:

Description

An inhibitor of long fatty acid acyl-CoA synthetase (IC50 = 6.3 μM in Raji cells) that interferes with lipid metabolism by inhibiting the de novo synthesis of triglycerides, diglycerides, and cholesterol esters; acts as a hypotensive vasodilator

Formal name: 2E,4E,7E-undecatrienal, nitrosohydrazone

Synonyms:  FR 900190|WS 1228A

Molecular weight: 207.3

CAS: 76896-80-5

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Microbial Metabolites||Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cardiovascular System|Cardiovascular Diseases|Hypertension||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Dyslipidemias||Research Area|Lipid Biochemistry|Acyl-CoAs||Research Area|Lipid Biochemistry|Glycerolipids||Research Area|Lipid Biochemistry|Sterol Lipids

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