Trapoxin A – 1 mg

Brand:
Cayman
CAS:
133155-89-2
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

Trapoxin A is a cyclotetrapeptide histone deacetylase (HDAC) inhibitor.{36959} It inhibits HDAC activity in a concentration-dependent and irreversible manner. Trapoxin A inhibits proliferation of NIH3T3 cells transformed by the oncogene v-sis (sis/NIH3T3; IC50 = ~200 ng/ml) and has detransformation activity, flattening sis/NIH3T3 cells when used at a concentration of 1 ng/ml.{21167} It also halts the cell cycle at the G2 phase in 3Y1 fibroblasts when used at a concentration of 10 nM and inhibits growth of TR303 cells resistant to trichostatin A (Item No. 89730) at a concentration of 50 ng/ml.{36959}  

 

Available on backorder

SKU: 26243 - 1 mg Category:

Description

An HDAC inhibitor; inhibits HDAC activity in a concentration-dependent and irreversible manner; inhibits proliferation of transformed sis/NIH3T3 cells (IC50 = ~200 ng/ml) and has detransformation activity at 1 ng/ml; halts the cell cycle at the G2 phase in 3Y1 fibroblasts at 10 nM; inhibits growth of trichostatin A-resistant cells at 50 ng/ml


Formal name: cyclo[(αS,2S)-α-amino-η-oxo-2-oxiraneoctanoyl-L-phenylalanyl-L-phenylalanyl-(2R)-2-piperidinecarbonyl]

Synonyms: 

Molecular weight: 602.7

CAS: 133155-89-2

Purity: ≥98%

Formulation: A solid


Product Type|Biochemicals|Small Molecule Inhibitors|Deacetylases||Research Area|Epigenetics, Transcription, & Translation|Erasers|Histone Deacetylation