A polyphenol with diverse biological activities; inhibits the cyclooxygenase and hydroperoxidase activities of COX-1 (EC50s = 15 and 3.7 μM

trans-Resveratrol – 500 mg

Brand:
Cayman
CAS:
501-36-0
Storage:
-20
UN-No:
Non-Hazardous - /

trans-Resveratrol is a polyphenol that has been found in grapes and has diverse biological activities.{3491,43362} It inhibits the cyclooxygenase and hydroperoxidase activities of COX-1 (EC50s = 15 and 3.7 μM, respectively) but not COX-2 (EC50s = >100 μM and 85 μM, respectively).{3491} trans-Resveratrol (200 μM) also activates sirtuin 1 (SIRT1), as well as inhibits a variety of targets including ERK1, JNK1, Src, PKCα, aromatase/CYP19, and DNA polymerases α and δ (IC50s = 37, 50, 20, in vitro.{13296,43362} It inhibits free radical formation induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014) in HL-60 cells and reduces the tumor incidence and number of tumors in a two-stage mouse model of skin cancer induced by TPA and 7,12-dimethyl-benz[a]anthracene (DMBA). trans-Resveratrol (3 and 8 mg/kg) inhibits carrageenan-induced paw edema in mice. Intravaginal administration of trans-resveratrol (12.5% v/v) inhibits herpes simplex virus 1 (HSV-1) and HSV-2 replication and delays the development of extravaginal disease in mouse models of vaginal HSV infection.{60119} It also prolongs lifespan in model organisms including C. elegans, D. melanogaster, and mice.{43362}  

 

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SKU: 70675 - 500 mg Category:

Description

A polyphenol with diverse biological activities; inhibits the cyclooxygenase and hydroperoxidase activities of COX-1 (EC50s = 15 and 3.7 μM, respectively); inhibits ERK1, JNK1, Src, PKCα, aromatase/CYP19, and DNA polymerases α and δ (IC50s = 37, 50, 20, in vitro and/or ex vivo; exhibits anticancer, anti-inflammatory, and antiviral activities in mice

Formal name: 5-[(1E)-2-(4-hydroxyphenyl)ethenyl]-1,3-benzenediol

Synonyms:  (E)-Resveratrol

Molecular weight: 228.2

CAS: 501-36-0

Purity: ≥98%

Formulation: A crystalline solid

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