An inhibitor of protein tyrosine phosphatases; increases phosphorylated substrates of the phosphatase SHP-1 in Jurkat T cells; selective for SHP-1 over SHP-2

TPI-1 – 25 mg

Brand:
Cayman
CAS:
79756-69-7
Storage:
-20
UN-No:
Non-Hazardous - /

TPI-1 is an inhibitor of protein tyrosine phosphatases.{41578} TPI-1 (10 ng/ml) increases phosphorylated substrates of the phosphatase SHP-1 in Jurkat T cells, including pLck-pY394, pZap70, and pSlp76. It is selective for SHP-1 over SHP-2, having low activity at the SHP-2 substrate pERK1/2. It increases pLck-pY394 levels by approximately 3.3-fold and increases the number of IFN-γ+ cells in mouse spleen ex vivo following a dose of approximately 3 mg/kg. Oral administration of TPI-1 (3 mg/kg per day) inhibits tumor growth in a B16 melanoma mouse xenograft model.  

 

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Description

An inhibitor of protein tyrosine phosphatases; increases phosphorylated substrates of the phosphatase SHP-1 in Jurkat T cells; selective for SHP-1 over SHP-2, having low activity at the SHP-2 substrate pERK1/2; increases pLck-pY394 levels by ~3.3-fold and increases the number of IFN-γ+ spleen cells in mouse spleen ex vivo (~3 mg/kg); inhibits tumor growth in a B16 melanoma mouse xenograft model (3 mg/kg per day, oral)

Formal name: 2-(2,5-dichlorophenyl)-2,5-cyclohexadiene-1,4-dione

Synonyms:  Tyrosine Phosphatase Inhibitor 1

Molecular weight: 253.1

CAS: 79756-69-7

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Phosphatases||Research Area|Cancer|Cell Signaling

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