A peptidomimetic of the critical TNF-α recognition loop on TNF receptor I complex that prevents ligand interaction with the receptor; interferes with both activating receptor activator of NF-κB (RANK) and TNF-α’s recruitment and activation of osteoclasts

TNF-α Antagonist – 5 mg

Brand:
Cayman
CAS:
199999-60-5
Storage:
-20
UN-No:
Non-Hazardous - /

TNF-α antagonist is an exocyclic peptide that mimics the critical TNF-α recognition loop on TNF receptor I complex and, thus, prevents ligand interaction with the receptor.{28742} By blocking the TNF receptor ligand contact site, this peptide interferes with both activating receptor activator of NF-κB (RANK) and TNF-α’s recruitment and activation of osteoclasts.{28741} TNF-α antagonist has been used to block bone resorption in the study of systemic bone loss in rheumatoid arthritis and inflammatory bone destruction.{28741}  

 

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Description

A peptidomimetic of the critical TNF-α recognition loop on TNF receptor I complex that prevents ligand interaction with the receptor; interferes with both activating receptor activator of NF-κB (RANK) and TNF-α’s recruitment and activation of osteoclasts, blocking bone resorption

Formal name: L-tyrosyl-L-cysteinyl-L-tryptophyl-L-seryl-L-glutaminyl-L-tyrosyl-L-leucyl-L-cysteinyl-L-tyrosine cyclic (2→8)-disulfide

Synonyms:  WP9QY

Molecular weight: 1,226.40

CAS: 199999-60-5

Purity:

Formulation: A crystalline solid

Product Type|Biochemicals|Peptides||Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Endocrinology & Metabolism|Bone Growth & Remodeling||Research Area|Immunology & Inflammation|Autoimmunity|Rheumatoid Arthritis

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