An antagonist that binds to M1

Tiotropium (bromide) – 5 mg

Brand:
Cayman
CAS:
136310-93-5
Storage:
-20
UN-No:
Non-Hazardous - /

Tiotropium is an antagonist that binds to M1, M2, and M3 muscarinic acetylcholine receptors (Kds = 0.43, 0.54, and 0.69 nM, respectively, for human receptors).{42255} It decreases acetylcholine-induced contraction of isolated guinea pig trachea in a concentration-dependent manner. In vivo, tiotropium (1 g/L inhaled aerosol) confers complete protection against acetylcholine-induced bronchospasms in anesthetized dogs. Formulations containing tiotropium have been used in the treatment of chronic obstructive pulmonary disease (COPD).  

 

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Description

An antagonist that binds to M1, M2, and M3 muscarinic acetylcholine receptors (Kds = 0.43, 0.54, and 0.69 nM, respectively, for human receptors); decreases acetylcholine-induced contraction of isolated guinea pig trachea in a concentration-dependent manner; confers complete protection against acetylcholine-induced bronchospasms in anesthetized dogs at 1.0 g/L inhaled aerosol,

Formal name: (1α,2β,4β,5α,7β)-7-[(2-hydroxy-2,2-di-2-thienylacetyl)oxy]-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.02,4]nonane, monobromide

Synonyms:  BA 679BR

Molecular weight: 472.4

CAS: 136310-93-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area

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