An imidazole antifungal; inhibits the growth of various fungi

Tioconazole – 1 g

Brand:
Cayman
CAS:
65899-73-2
Storage:
-20
UN-No:
Non-Hazardous - /

Tioconazole is an imidazole antifungal that inhibits the growth of various fungi, including C. albicans, C. neoformans, A. fumigatus, and T. rubrum (MICs = 4.7, 0.1, 5.7, and 0.5 µg/ml, respectively).{25584,48062} It inhibits C-14 demethylation of sterols in a cell-free C. albicans homogenate (IC50 = 50-80 nM).{48063} Tioconazole (2% w/v cream) reduces the number of viable Candida cells recovered from the vagina in a mouse model of vaginal candidiasis.{48064} Formulations containing tioconazole have been used in the treatment of vaginal yeast infections.  

 

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SKU: 26069 - 1 g Category:

Description

An imidazole antifungal; inhibits the growth of various fungi, including C. albicans, C. neoformans, A. fumigatus, and T. rubrum (MICs = 4.7, 0.1, 5.7, and 0.5 µg/ml, respectively); inhibits C-14 demethylation of sterols in a cell-free C. albicans homogenate (IC50 = 50-80 nM); reduces the number of viable Candida cells recovered from the vagina in a mouse model of vaginal candidiasis at 2% w/v in a cream

Formal name: 1-[2-[(2-chloro-3-thienyl)methoxy]-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole

Synonyms:  (±)-Tioconazole

Molecular weight: 387.7

CAS: 65899-73-2

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Antifungals|Imidazoles||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Fungal Diseases|Aspergillosis||Research Area|Infectious Disease|Fungal Diseases|Candidiasis

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