A synthetic heme analog that selectively inhibits HO-1 (Ki = 11 nM) over HO-2 (IC50 = 7.5 µM); weakly inhibits eNOS and soluble guanylyl cyclase (IC50s = 35 and 30 nM

Tin Protoporphyrin IX (chloride) – 25 mg

Brand:
Cayman
CAS:
14325-05-4
Storage:
-20
UN-No:
Non-Hazardous - /

Heme oxygenase (HO) converts protoheme to biliverdin, which in turn is enzymatically metabolized to bilirubin (Item No. 17161). While HO-2 is constitutively expressed, HO-1 can be induced by its heme substrate as well as by heavy metals, oxidizing agents, and other environmental stresses.{19790,4647,17438} Tin protoporphyrin IX (SnPPIX) is a synthetic heme analog that selectively inhibits HO-1 (Ki = 11 nM) over HO-2 (IC50 = 7.5 µM).{26672,26673} It also weakly inhibits endothelial nitric oxide synthase and soluble guanylyl cyclase (IC50s = 35 and 30 nM, respectively).{26673} SnPPIX prevents hyperbilirubinemia in neonates by blocking HO-1 activity that increases postnatally.{26672} It is rapidly cleared from plasma and persists in certain tissues, including kidney, liver, and spleen.{26671} SnPPIX is commonly used as a tool to study the role of HO-1 activity in cells and in animals.{26675,26674}  

 

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Description

A synthetic heme analog that selectively inhibits HO-1 (Ki = 11 nM) over HO-2 (IC50 = 7.5 µM); weakly inhibits eNOS and soluble guanylyl cyclase (IC50s = 35 and 30 nM, respectively); prevents hyperbilirubinemia in neonates by blocking HO-1 activity that increases postnatally

Formal name: (OC-6-13)-dichloro[7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-κN21,κN22,κN23,κN24]-stannate(2-), dihydrogen

Synonyms:  NSC 267099|SnPPIX

Molecular weight: 750.3

CAS: 14325-05-4

Purity:

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Nitric Oxide Synthases||Research Area|Cardiovascular System|Vasculature|Endothelium

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