A potent

Tin Mesoporphyrin IX (chloride) – 10 mg

Brand:
Cayman
CAS:
106344-20-1
Storage:
-20
UN-No:
Non-Hazardous - /

Heme oxygenases (HOs) convert protoheme to biliverdin, which in turn is enzymatically metabolized to bilirubin (Item No. 17161). Tin mesoporphyrin IX is a potent, competitive inhibitor of HO activity in vitro (Ki = 14 nM).{30698} It inhibits hepatic, renal, and splenic HO activity in vivo for extended periods of time.{30698} Tin mesoporphyrin IX blocks bilirubin production in vivo, decreasing HO activity in animal models of hyperbilirubinemia.{30698,26672,30699} Tin mesoporphyrin IX can be used to study the physiological roles of induced HO-1 expression in animal models.{30697,30700,30701}  

 

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Description

A potent, competitive inhibitor of HO activity in vitro (Ki = 14 nM); inhibits hepatic, renal, and splenic HO activity in vivo for extended periods of time; blocks bilirubin production in vivo, decreasing HO activity in animal models of hyperbilirubinemia

Formal name: (OC-6-13)-dichloro[7,12-diethyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-κN21,κN22,κN23,κN24]-stannate(2-), dihydrogen

Synonyms:  NSC 267099|SnMP

Molecular weight: 754.3

CAS: 106344-20-1

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors||Research Area

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