A steroidal saponin with diverse biological activities; inhibits superoxide generation in isolated human neutrophils from 20-100 µM; reduces EV71-induced cell death in Vero cells (IC50 = 4.3 µM); inhibits ADP-induced platelet aggregation in isolated rabbit PRP at 20

Timosaponin BII – 10 mg

Brand:
Cayman
CAS:
136656-07-0
Storage:
-20
UN-No:
Non-Hazardous - /

Timosaponin BII (TB-II) is a steroidal saponin that has been found in Anemarrhenae and has diverse biological activities.{59438,55411,59439} TB-II (20-100 µM) inhibits superoxide generation induced by phorbol 12-myristate 13-acetate (PMA; Item No. 10008014), N-formyl-Met-Leu-Phe (fMLP; Item No. 21495), or arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607) in isolated human neutrophils.{59438} It reduces cell death induced by enterovirus 71 (EV71) in Vero cells (IC50 = 4.3 µM).{55411} TB-II (20, 40, and 80 mg/ml) inhibits ADP-induced platelet aggregation in isolated rabbit platelet-rich plasma (PRP).{59439} TB-II (3 and 6 mg/kg) increases activated partial thromboplastin time (APTT) and decreases the wet weight and length of thrombi in Chandler’s ex vivo thrombosis model.  

 

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SKU: 30644 - 10 mg Category:

Description

A steroidal saponin with diverse biological activities; inhibits superoxide generation in isolated human neutrophils from 20-100 µM; reduces EV71-induced cell death in Vero cells (IC50 = 4.3 µM); inhibits ADP-induced platelet aggregation in isolated rabbit PRP at 20, 40, and 80 mg/ml; increases APTT and decreases the wet weight and length of thrombi in Chandler’s ex vivo thrombosis model at 3 and 6 mg/kg

Formal name: (3β,5β,22α,25S)-26-(β-D-glucopyranosyloxy)-22-hydroxyfurostan-3-yl 2-O-β-D-glucopyranosyl-β-D-galactopyranoside

Synonyms:  TB-II

Molecular weight: 921.1

CAS: 136656-07-0

Purity: ≥98%

Formulation: A crystalline solid

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