A steroidal saponin; inhibits HGF-induced invasive activity and COX-2 gene expression in MDA-MB-231 breast cancer cells and B16-F10 melanoma cells; reduces the number of metastatic nodules in B16-F10 melanoma cell-treated mice; reduces 2

Timosaponin AIII – 1 mg

Brand:
Cayman
CAS:
41059-79-4
Storage:
-20
UN-No:
Non-Hazardous - /

Timosaponin AIII (TAIII) is a steroidal saponin isolated from A. asphodeloides that has anticancer, anti-inflammatory, and antithrombotic activities and also improves learning and memory deficits in mice.{36060,36061,36062,36063,36064} It inhibits invasive activity and COX-2 gene expression induced by hepatocyte growth factor (HGF) in MDA-MB-231 breast cancer cells and B16-F10 melanoma cells in a concentration-dependent manner.{36063,36064} TAIII (25 mg/kg) significantly reduces the number of metastatic nodules in B16-F10 melanoma cell-treated mice.{36063} Oral administration of TAIII reduces 2,3,4-trinitrobenzene sulfonic acid-induced colon shortening, myeloperoxidase activity, NF-kB activation, and IL-1β, TNF-α, and IL-6 levels in mice.{36061} TAIII reduces mortality and venous thrombus weight in mice with acute thromboembolism.{36062} It inhibits acetylcholinesterase in vitro (AChE; IC50 = 35.4 μM) and improves scopolamine-induced learning and memory deficits in mice, as measured using the passive avoidance test and Morris water maze.{36060}  

 

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Description

A steroidal saponin; inhibits HGF-induced invasive activity and COX-2 gene expression in MDA-MB-231 breast cancer cells and B16-F10 melanoma cells; reduces the number of metastatic nodules in B16-F10 melanoma cell-treated mice; reduces 2,3,4-trinitrobenzene sulfonic acid-induced colon shortening, myeloperoxidase activity, NF-kB activation, and IL-1β, TNF-α, and IL-6 levels in mice; reduces mortality and venous thrombus weight in mice with acute thromboembolism; inhibits AChE in vitro (IC50 = 35.4 μM)

Formal name: (3β,5β,25S)-spirostan-3-yl 2-O-β-D-glucopyranosyl-β-D-galactopyranoside

Synonyms:  TAIII

Molecular weight: 740.9

CAS: 41059-79-4

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Saponins||Product Type|Biochemicals|Small Molecule Inhibitors|Acetylcholine Turnover||Research Area|Cancer|Cell Migration & Metastasis||Research Area|Cancer|Cell Signaling|Growth Factor Receptor Signaling||Research Area|Cancer|Cell Signaling|NF-κB Signaling||Research Area|Cardiovascular System|Blood|Thrombosis||Research Area|Immunology & Inflammation||Research Area|Neuroscience|Behavioral Neuroscience|Learning & Memory

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