An inhibitor of BRK/PTK6 (IC50 = 3.15 nM); selective for BRK/PTK6 over HER2 (IC50 = 1

Tilfrinib – 5 mg

Brand:
Cayman
CAS:
1600515-49-8
Storage:
-20
UN-No:
Non-Hazardous - /

Tilfrinib is an inhibitor of breast tumor kinase/protein tyrosine kinase 6 (BRK/PTK6; IC50 = 3.15 nM).{42337,42338} It is selective for BRK/PTK6 over HER2 (IC50 = 1,300 nM).{42338} Tilfrinib inhibits the growth of MCF-7, HS-578/T, and BT-549 breast cancer cells in vitro (GI50s = 0.99, 1.02, and 1.58 μM, respectively).{42337}  

 

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SKU: 25647 - 5 mg Category:

Description

An inhibitor of BRK/PTK6 (IC50 = 3.15 nM); selective for BRK/PTK6 over HER2 (IC50 = 1,300 nM); inhibits the growth of MCF-7, HS-578/T, and BT-549 breast cancer cells in vitro (GI50s = 0.99, 1.02, and 1.58 μM, respectively) ,

Formal name: 3-(9H-pyrido[2,3-b]indol-4-ylamino)-phenol

Synonyms: 

Molecular weight: 275.3

CAS: 1600515-49-8

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Kinase Inhibitors|SRC Family||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Signaling|SRC Family Signaling

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