A steroidal sapogenin with diverse biological activities; increases the proliferation rate of

Tigogenin – 250 mg

Brand:
Cayman
CAS:
77-60-1
Storage:
-20
UN-No:
Non-Hazardous - /

Tigogenin is a steroidal sapogenin that has been found in A. sisalana and has diverse biological activities.{38813,46840,46841,46842} It increases the proliferation rate of, as well as mRNA levels of genes encoding the osteoblastic differentiation markers Cbfa1, collagen type I, and osteocalcin in, mouse bone marrow stromal cells (BMSCs) in a concentration-dependent manner.{46840} It also increases matrix calcium deposition in BMSCs when used at concentrations of 30 and 90 μM. Tigogenin is active against the fungus A. fumigatus (MIC50 = 16 μg/ml).{46841} It inhibits carrageenan-induced paw edema in rats when administered at a dose of 4.2 μg/kg.{46842}  

 

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SKU: 30137 - 250 mg Category:

Description

A steroidal sapogenin with diverse biological activities; increases the proliferation rate of, as well as mRNA levels of genes encoding the osteoblastic differentiation markers Cbfa1, collagen type I, and osteocalcin in, mouse BMSCs in a concentration-dependent manner; increases matrix calcium deposition in BMSCs at 30 and 90 μM; active against the fungus A. fumigatus (MIC50 = 16 μg/ml); inhibits carrageenan-induced paw edema in rats at 4.2 μg/kg

Formal name: (3β,5α,25R)-spirostan-3-ol

Synonyms:  NSC 93754

Molecular weight: 416.6

CAS: 77-60-1

Purity: ≥90%

Formulation: A solid

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