A glycylcycline antibiotic; binds to the bacterial 30S ribosome

Tigecycline – 5 mg

Brand:
Cayman
CAS:
220620-09-7
Storage:
-20
UN-No:
Non-Hazardous - /

Tigecycline is a broad-spectrum glycylcycline antibiotic that binds to the bacterial 30S ribosome, blocking the entry of transfer RNA, which halts protein synthesis and inhibits bacterial growth.{22659} It is active against a panel of 1,924 European clinical bacterial isolates including S. aureus, S. epidermidis, S. pneumoniae, E. faecalis, E. faecium, E. coli, K. pneumoniae, P. aeruginosa, and P. mirabilis strains (MICs = In vivo, tigecycline (6.25 mg/kg twice daily for 5 days) decreases levels of C. difficile cytotoxin activity and spore formation in cecum and colon in a mouse model of C. difficile infection.{42396} Formulations containing tigecycline have been used in the treatment of a variety of bacterial infections.  

 

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Description

A glycylcycline antibiotic; binds to the bacterial 30S ribosome, blocking the entry of transfer RNA, which halts protein synthesis and inhibits bacterial growth; active against a panel of 1,924 European clinical bacterial isolates (MICs = C. difficile cytotoxin activity and spore formation in cecum and colon in a mouse model of C. difficile infection at 6.25 mg/kg twice daily for 5 days ,

Formal name: 4S,7-bis(dimethylamino)-9-[[2-[(1,1-dimethylethyl)amino]acetyl]amino]-1,4S,4aS,5,5aR,6,11,12a-octahydro-3,10,12,12aS-tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide

Synonyms:  GAR 936|Glycylcycline

Molecular weight: 585.7

CAS: 220620-09-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antibiotics||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases|Pneumonia

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