Reversibly and selectively blocks Tie2 kinase activity (IC50 = 250 nM); reduces angiogenesis in a Matrigel neovascularization assay and delays tumor growth in MOPC-315 plasmacytoma and SVR angiosarcoma xenograft models

Tie2 Kinase Inhibitor – 1 mg

Brand:
Cayman
CAS:
948557-43-5
Storage:
-20
UN-No:
Non-Hazardous - /

Tunica interna endothelial cell kinase 2 (Tie2, also known as angiopoietin-1 receptor or tek) is an endothelium-specific receptor tyrosine kinase important for the development of embryonic vasculature and for angiogenesis and vascular maintenance in adult tissues.{10075} Tie2 kinase inhibitor reversibly and selectively blocks Tie2 kinase activity with an IC50 value of 250 nM.{29691} It is 200-fold more potent for inhibition of Tie2 compared to p38.{29691} Tie2 kinase inhibitor has been shown to reduce angiogenesis in a Matrigel neovascularization assay and to delay tumor growth in MOPC-315 plasmacytoma and SVR angiosarcoma xenograft models.{29691,29690}  

 

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Description

Reversibly and selectively blocks Tie2 kinase activity (IC50 = 250 nM); reduces angiogenesis in a Matrigel neovascularization assay and delays tumor growth in MOPC-315 plasmacytoma and SVR angiosarcoma xenograft models

Formal name: 4-[4-(6-methoxy-2-naphthalenyl)-2-[4-(methylsulfinyl)phenyl]-1H-imidazol-5-yl]-pyridine

Synonyms:  Tunica Interna Endothelial Cell Kinase 2 Inhibitor

Molecular weight: 439.5

CAS: 948557-43-5

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|Other Receptor Tyrosine Kinases||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Angiogenesis||Research Area|Cancer|Cell Signaling

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