A thiadiazolidinone that prevents inflammation and neurodegeneration when injected into rat hippocampus concurrently with kainic acid; irreversibly inhibits GSK3β with an IC50 value of 5 nM when used with a one hour preincubation

Tideglusib – 5 mg

Brand:
Cayman
CAS:
865854-05-3
Storage:
-20
UN-No:
Non-Hazardous - /

Tideglusib is a thiadiazolidinone that prevents inflammation and neurodegeneration when injected into rat hippocampus concurrently with kainic acid, a compound that causes excitotoxicity.{27696} Tideglusib-induced neuroprotection, in this model, is attenuated by the PPARγ antagonist GW9662 (Item No. 70785).{27696} Interestingly, tideglusib also irreversibly inhibits glycogen synthase kinase-3β (GSK3β) with an IC50 value of 5 nM when used with a one hour preincubation, increasing to 0.1-1 µM without preincubation.{27697,27698} Several GSK3 inhibitors, including tideglusib, promote hippocampal neurogenesis both in vitro and in vivo, suggesting suitability in Alzheimer’s therapy.{27698,27699}  

 

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Description

A thiadiazolidinone that prevents inflammation and neurodegeneration when injected into rat hippocampus concurrently with kainic acid; irreversibly inhibits GSK3β with an IC50 value of 5 nM when used with a one hour preincubation, increasing to 0.1-1 µM without preincubation

Formal name: 2-(1-naphthalenyl)-4-(phenylmethyl)-1,2,4-thiadiazolidine-3,5-dione

Synonyms:  NP031112

Molecular weight: 334.4

CAS: 865854-05-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|GSK3||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Neuroscience|Neurodegenerative Disorders|Alzheimer’s Disease

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