A P2Y12 receptor antagonist; inhibits collagen-

Ticlopidine (hydrochloride) – 5 g

Brand:
Cayman
CAS:
53885-35-1
Storage:
-20
UN-No:
Non-Hazardous - /

Ticlopidine is a thienopyridine P2Y12 receptor antagonist.{37611} It inhibits aggregation of human platelets induced by collagen, arachidonic acid (Item No. 90010), and ADP (Item No. 16778; IC50s = 75, 600, and 1,300 μM, respectively).{37612} It also inhibits ADP-induced aggregation of rat platelets and decreases thrombus weight in vivo in a rat model of arterio-venous shunt thrombosis when administered at a dose of 100 mg/kg.{23697} Ticlopidine (300 mg/kg) inhibits healing of acetic acid-induced gastric ulcers in rats.{37613} Formulations containing ticlopidine have been used in the prevention of thrombotic stroke.  

 

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Description

A P2Y12 receptor antagonist; inhibits collagen-, arachidonic acid-, and ADP-induced aggregation of human platelets (IC50s = 75, 600, and 1,300 μM, respectively); inhibits ADP-induced aggregation of rat platelets; decreases thrombus weight in a rat model of arterio-venous shunt thrombosis at 100 mg/kg; inhibits healing of acetic acid-induced gastric ulcers in rats at 300 mg/kg

Formal name: 5-[(2-chlorophenyl)methyl]-4,5,6,7-tetrahydro-thieno[3,2-c]pyridine, monohydrochloride

Synonyms: 

Molecular weight: 300.2

CAS: 53885-35-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Cardiovascular System|Blood|Coagulation & Hemostasis||Research Area|Cardiovascular System|Blood|Thrombosis||Research Area|Cardiovascular System|Cardiovascular Diseases|Stroke

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