A reversible purinergic P2Y12 receptor antagonist (Ki = 14 nM; IC50 = 1.8 μM)

Ticagrelor – 5 mg

Brand:
Cayman
CAS:
274693-27-5
Storage:
-20
UN-No:
Non-Hazardous - /

Ticagrelor is a reversible antagonist of the platelet purinergic P2Y12 receptor (Ki = 14 nM; IC50 = 1.8 μM), which is the main receptor responsible for ADP-induced platelet aggregation.{25099,23701} It functions by directly changing the conformation of the P2Y12 receptor to inhibit ADP binding.{23699} Formulations containing ticagrelor have been used to reduce the rate of thrombotic cardiovascular events in patients with acute coronary syndrome.  

 

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Description

A reversible purinergic P2Y12 receptor antagonist (Ki = 14 nM; IC50 = 1.8 μM)

Formal name: (1S,2S,3R,5S)-3-[7-[[(1R,2S)-2-(3,4-difluorophenyl)cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-5-(2-hydroxyethoxy)-1,2-cyclopentanediol

Synonyms:  AR-C 126532XX|AZD 6140

Molecular weight: 522.6

CAS: 274693-27-5

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Allosteric Modulators||Research Area|Cardiovascular System|Blood|Coagulation & Hemostasis||Research Area|Cardiovascular System|Blood|Thrombosis||Research Area|Cardiovascular System|Cardiovascular Diseases

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