Induces the expression of TRAIL at 1-5 µM in a p53-independent manner; orally active

TIC10 – 10 mg

Brand:
Cayman
CAS:
1616632-77-9
Storage:
-20
UN-No:
Non-Hazardous - /

TIC10 induces the expression of TNF-related apoptosis-inducing ligand (TRAIL) at 1-5 µM in a p53-independent manner.{28066} It is orally active, stable, and crosses the blood-brain barrier.{28066} The induction of TRAIL results from dual inhibition of Akt and ERK1/2 combined with nuclear translocation of the transcription factor FOXO3a.{28066} TIC10 suppresses the growth of orthotopic human glioblastoma multiforme tumors in mice.{28066}  

 

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Description

Induces the expression of TRAIL at 1-5 µM in a p53-independent manner; orally active, stable, and crosses the blood-brain barrier; suppresses the growth of orthotopic human glioblastoma multiforme tumors in mice

Formal name: 2,4,6,7,8,9-hexahydro-4-[(2-methylphenyl)methyl]-7-(phenylmethyl)-imidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1H)-one

Synonyms:  ONC201

Molecular weight: 386.5

CAS: 1616632-77-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|PKB/Akt||Product Type|Biochemicals|Kinase Inhibitors|RAS/RAF/MEK/ERK/MAPK||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer

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