A COX inhibitor and NSAID with anti-inflammatory and analgesic activities; inhibits synthesis of PGE2 and PGF2α from arachidonic acid in bovine seminal vesicle microsomes and inhibits TXB2 formation in human umbilical cord arteries bathed in clotting human blood (IC50 = 0.71 μM); has anti-inflammatory activity in rat models of carrageenan-induced edema and adjuvant-induced arthritis and has analgesic activity in acetic acid- or phenylquinone-induced writhing tests in rodents

Tiaprofenic Acid – 5 mg

Brand:
Cayman
CAS:
33005-95-7
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

Tiaprofenic acid is a COX inhibitor and a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory and analgesic activities.{45285} It inhibits synthesis of prostaglandin E2 (PGE2; Item No. 14010) and PGF2α (Item Nos. 16010 | 16020) from arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607) in bovine seminal vesicle microsomes and inhibits thromboxane B2 (TXB2; Item No. 19030) formation in human umbilical cord arteries bathed in clotting human blood (IC50 = 0.71 μM).{45286,45285} Tiaprofenic acid has anti-inflammatory activity in rat models of carrageenan-induced edema and adjuvant-induced arthritis and has analgesic activity in acetic acid- or phenylquinone-induced writhing tests in rodents.{45285}  

 

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SKU: 27364 - 5 mg Category:

Description

A COX inhibitor and NSAID with anti-inflammatory and analgesic activities; inhibits synthesis of PGE2 and PGF2α from arachidonic acid in bovine seminal vesicle microsomes and inhibits TXB2 formation in human umbilical cord arteries bathed in clotting human blood (IC50 = 0.71 μM); has anti-inflammatory activity in rat models of carrageenan-induced edema and adjuvant-induced arthritis and has analgesic activity in acetic acid- or phenylquinone-induced writhing tests in rodents

Formal name: 5-benzoyl-α-methyl-2-thiopheneacetic acid

Synonyms:  RU 15060|Tiaprofen

Molecular weight: 260.3

CAS: 33005-95-7

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Small Molecule Inhibitors|Cyclooxygenases||Research Area|Immunology & Inflammation|Autoimmunity|Rheumatoid Arthritis||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Prostaglandins||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway||Research Area|Neuroscience|Pain Research

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