Description
A Cdk7 inhibitor (IC50 = 13.9 nM); selective for Cdk7 over Cdk1, -2, -5, -8, and -9 (IC50s = 96.9, 222, 134, 6,830, and 194 nM, respectively); reduces proliferation of BT-549, HCC70, and MDA-MB-468 TNBC cells; reduces tumor volume in an MDA-MB-231 mouse xenograft model at 10 mg/kg; reduces tumor weight and volume, as well as the number of lung metastases, in an SJSA-1 osteosarcoma orthotopic mouse xenograft model
Formal name: N-[3-[[5-chloro-4-(1H-indol-3-yl)-2-pyrimidinyl]amino]phenyl]-3-[[(2E)-4-(dimethylamino)-1-oxo-2-buten-1-yl]amino]-benzamide
Synonyms:
Molecular weight: 566.1
CAS: 1604810-84-5
Purity: ≥98%
Formulation: A solid
