A natural phytochemical with anti-inflammatory effects; inhibits the growth of leukemia cells (IC50 = 1.5 μg/ml)

Thymoquinone – 1 g

Brand:
Cayman
CAS:
490-91-5
Storage:
-20
UN-No:
Non-Hazardous - /

The black seeds of Nigella have long been ingested to treat a broad range of diseases, including inflammation and cancer.{23958} Thymoquinone is a natural phytochemical isolated from the seeds of N. sativa.{23958} It has anti-inflammatory effects, blocking the synthesis of leukotrienes.{23955,23958} Thymoquinone inhibits the growth of leukemia cells (IC50 = 1.5 μg/ml), inducing apoptosis by down-regulating the expression of Bcl-2 while up-regulating Bax expression.{23957} In addition to blocking cell proliferation and triggering apoptosis, thymoquinone (15 μM) suppresses STAT3-regulated gene expression and prevents angiogenesis.{23959,23956}  

 

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Description

A natural phytochemical with anti-inflammatory effects; inhibits the growth of leukemia cells (IC50 = 1.5 μg/ml), inducing apoptosis; at 15 μM, suppresses STAT3-regulated gene expression and prevents angiogenesis

Formal name: 2-methyl-5-(1-methylethyl)-2,5-cyclohexadiene-1,4-dione

Synonyms:  NSC 2228

Molecular weight: 164.2

CAS: 490-91-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products||Research Area|Cancer|Angiogenesis||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Signaling|JAK/STAT Signaling||Research Area|Cancer|Transcription Factors|STATs||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Leukotrienes

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