A pentapeptide fragment of thymopoietin; induces prothymocyte differentiation in isolated mouse splenocytes at 0.018-18 µM; increases proliferation of

Thymopentin – 50 mg

Brand:
Cayman
CAS:
69558-55-0
Storage:
-20
UN-No:
Non-Hazardous - /

Thymopentin is a pentapeptide fragment of thymopoietin.{52518} It induces prothymocyte differentiation in isolated mouse splenocytes when used at concentrations ranging from 0.018 to 18 µM. Thymopentin (1 µg/ml) increases proliferation of, and phytohemagglutinin-stimulated IL-2 production in, isolated human peripheral blood lymphocytes (PBLs).{52519} It reduces the number of splenic autologous rosette-forming cells in athymic mice when administered at doses ranging from 0.02 to 10 mg/kg.{52518} Adoptive cell transfer of splenocytes isolated from tumor-bearing mice administered thymopentin (100 ng/animal) reduces recipient tumor growth in a murine Lewis lung carcinoma model.{52520}  

 

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Description

A pentapeptide fragment of thymopoietin; induces prothymocyte differentiation in isolated mouse splenocytes at 0.018-18 µM; increases proliferation of, and phytohemagglutinin-stimulated IL-2 production in, isolated human PBLs at 1 µg/ml; reduces the number of splenic autologous rosette-forming cells in athymic mice at 0.02-10 mg/kg; adoptive cell transfer of splenocytes isolated from tumor-bearing mice administered thymopentin (100 ng/animal) reduces recipient tumor growth in a murine Lewis lung carcinoma model

Formal name: L-arginyl-L-lysyl-L-α-aspartyl-L-valyl-L-tyrosine

Synonyms:  RKDVY|Thymopoietin II (32-36)|Thymopoietin Pentapeptide|TP5

Molecular weight: 679.8

CAS: 69558-55-0

Purity: ≥98%

Formulation: A crystalline solid

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