A monocationic surfactant with diverse biological activities; an inhibitor of F. tularensis AcpB (Ki = 0.59 µM) and C. albicans V-ATPase (EC50 = 69 µM); inhibits osteoclastogenesis RANKL-induced osteoclastogenesis in BMDMs; inhibits bone resorption by mature osteoclasts at 100 and 200 nM; prevents LPS-induced bone loss in a calvarial osteolytic mouse model at 5 mg/kg per day; induces mortality in C. oncophora

Thonzonium (bromide) – 10 mg

Brand:
Cayman
CAS:
553-08-2
Storage:
-20
UN-No:
Non-Hazardous - /

Thonzonium is a monocationic surfactant with diverse biological activities.{53955,53956,53957,53958} It is an inhibitor of F. tularensis acid phosphatase B (AcpB; Ki = 0.59 µM) and the vacuolar ATPase (V-ATPase) proton pump in C. albicans (EC50 = 69 µM in purified vacuolar membrane vesicles).{53955,53956} Thonzonium (25-400 nM) inhibits osteoclastogenesis induced by RANKL in bone marrow-derived macrophages (BMDMs) and inhibits bone resorption by mature osteoclasts in a V-ATPase-independent manner when used at concentrations of 100 and 200 nM.{53957} It prevents bone loss induced by LPS in a calvarial osteolytic mouse model when administered at a dose of 5 mg/kg per day. Thonzonium induces mortality in the helminths C. oncophora, O. ostertagi, H. contortus, and T. circumcincta with EC50 values of 4.5, 10.8, 5.1, and 6.7 µM, respectively, but is cytotoxic to HEK293 and RAW 264.7 cells with CC50 values of 9.2 and 5.7 µM, respectively.{53958} Formulations containing thonzonium as a surfactant have been used in the treatment of external auditory canal infections, as well as mastoidectomy and fenestration cavity infections.  

 

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Description

A monocationic surfactant with diverse biological activities; an inhibitor of F. tularensis AcpB (Ki = 0.59 µM) and C. albicans V-ATPase (EC50 = 69 µM); inhibits osteoclastogenesis RANKL-induced osteoclastogenesis in BMDMs; inhibits bone resorption by mature osteoclasts at 100 and 200 nM; prevents LPS-induced bone loss in a calvarial osteolytic mouse model at 5 mg/kg per day; induces mortality in C. oncophora, O. ostertagi, H. contortus, and T. circumcincta (EC50s = 4.5, 10.8, 5.1, and 6.7 µM, respectively) but is cytotoxic to HEK293 and RAW 264.7 cells (CC50s = 9.2 and 5.7 µM, respectively)

Formal name: N-[2-[[(4-methoxyphenyl)methyl]-2-pyrimidinylamino]ethyl]-N,N-dimethyl-1-hexadecanaminium, monobromide

Synonyms:  NC 1264

Molecular weight: 591.7

CAS: 553-08-2

Purity: ≥98%

Formulation: A crystalline solid

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