A typical antipsychotic; selectively binds to dopamine D2 over D1

Thiothixene – 5 mg

Brand:
Cayman
CAS:
5591-45-7
Storage:
-20
UN-No:
Non-Hazardous - /

Thiothixene is a typical antipsychotic.{39485} It selectively binds to dopamine D2 over D1, D3, and D4 receptors (Kis = 0.417, 338, 186.2, and 363.1 nM, respectively). Thiothixene also binds to various serotonin (5-HT), histamine H1, α1- and α2-adrenergic, muscarinic acetylcholine, and sigma receptors (Kis = 15-5,754 nM) as well as the dopamine, norepinephrine, and serotonin transporters (Kis = 3.16-30 μM). In vivo, thiothixene reduces spontaneous and amphetamine-induced locomotor activity in rats.{39486} It enhances latent inhibition, as measured by a decreased lick latency in response to light and foot shock stimuli, which is a measure of selective attention in rats.{39487} Thiothixene also increases competitive behavior in submissive mice, indicating antidepressant-like behavior.{39488} Formulations containing thiothixene have been used in the treatment of schizophrenia and bipolar mania.  

 

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Description

A typical antipsychotic; selectively binds to dopamine D2 over D1, D3, and D4 receptors (Kis = 0.417, 338, 186.2, and 363.1 nM, respectively); binds to various 5-HT, histamine H1, α1- and α2-adrenergic, muscarinic acetylcholine, and sigma receptors (Kis = 15-5,754 nM) as well as the dopamine, norepinephrine, and serotonin transporters (Kis = 3.16-30 μM); reduces spontaneous and amphetamine-induced locomotor activity in rats; enhances latent inhibition in rats; increases competitive behavior in submissive mice

Formal name: N,N-dimethyl-9-[3-(4-methyl-1-piperazinyl)propylidene]-9H-thioxanthene-2-sulfonamide

Synonyms:  cis-Thiothixene|CP 12,252-1|NSC 108165|P 4657B

Molecular weight: 443.6

CAS: 5591-45-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology||Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Neuroscience|Behavioral Neuroscience|Bipolar Disorder||Research Area|Neuroscience|Behavioral Neuroscience|Depression||Research Area|Neuroscience|Behavioral Neuroscience|Schizophrenia & Psychosis

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