A natural peptide thiazole antibiotic that inhibits FoxM1 in mammalian cells

Thiostrepton – 1 g

Brand:
Cayman
CAS:
1393-48-2
Storage:
-20
UN-No:
Non-Hazardous - /

The mammalian transcription factor forkhead box M1 (FoxM1) is induced during G1 phase, with expression continuing through S phase and mitosis. Thiostrepton is a natural peptide thiazole antibiotic that inhibits FoxM1 in mammalian cells, preventing the expression of FoxM1-regulated genes, which includes FoxM1 itself.{24929,24931} Through this mechanism, thiostrepton prevents proliferation and induces apoptosis in human cancer cells.{24929} These effects correlate with the ability of thiostrepton to act as a proteasome inhibitor.{31116}  

 

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Description

A natural peptide thiazole antibiotic that inhibits FoxM1 in mammalian cells, preventing the expression of FoxM1-regulated genes; prevents proliferation and induces apoptosis in human cancer cells; also acts as a proteasome inhibitor

Formal name: N-​[(7R,​8S)​-​2-​carboxy-​7,​8-​dihydro-​8-​hydroxy-​4-​[(1S)​-​1-​hydroxyethyl]​-​7-​quinolinyl]​-​L-​isoleucyl-​L-​alanyl-​2,​3-​didehydroalanyl-​L-​alanyl-​2-​[(4aR,​11S,​14Z,​18S,​21S,​28S,​32aS)​-​4a-​amino-​21-​[(1S,​2R)​-​1,​2-​dihydroxy-​1-​methylpropyl]​-​14-​ethylidene-​3,​4,​4a,​9,​10,​11,​12,​13,​14,​18,​19,​20,​21,​27,​28,​32a-​hexadecahydro-​11,​28-​bis[(1R)​-​1-​hydroxyethyl]​-​9,​12,​19,​26-​tetraoxo-​17H,​26H-​8,​5:18,​15:25,​22:32,​29-​tetranitrilo-​5H,​15H-​pyrido[3,​2-​m]​[1,​11,​17,​24,​4,​7,​20,​27]​tetrathiatetraazacyc​lotriacontin-​2-​yl]​-​4-​thiazolecarbonyl-​2,​3-​didehydroalanyl-​2,​3-​didehydro-​alaninamide, (1→528)​-​lactone

Synonyms:  Bryamycin|NSC 170365|NSC 81722|Thiactin|Thiostreptin A

Molecular weight: 1,664.90

CAS: 1393-48-2

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products||Product Type|Biochemicals|Peptides||Product Type|Biochemicals|Small Molecule Inhibitors|Peptidases & Proteases||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Transcription Factors||Research Area|Cell Biology|Proteolysis|Ubiquitin/Proteasome System||Research Area|Epigenetics, Transcription, & Translation|Transcription Factors

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